GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2275426 | 1 | rs10890361 | chr1:46346234 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -10.29 | 9.25E-24 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890361 | chr1:46346234 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.45 | 0.000579 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890361 | chr1:46346234 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.41 | 7.77E-8 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890363 | chr1:46356148 | CCDC163P | chr1:45960581-45965646:- | 0.4 | 11.94 | 5.93E-31 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890363 | chr1:46356148 | MUTYH | chr1:45794915-45806142:- | -0.13 | -4.99 | 7.03E-7 | Body mass index |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | DCPS | chr11:126173647-126215643:+ | 0.16 | 3.93 | 9.07E-5 | Schizophrenia |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | EI24 | chr11:125439298-125454574:+ | 0.16 | 3.46 | 0.000556 | Schizophrenia |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | HYLS1 | chr11:125753509-125770540:+ | 0.2 | 4.51 | 7.07E-6 | Schizophrenia |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | PUS3 | chr11:125763380-125773116:- | 0.15 | 3.41 | 0.000667 | Schizophrenia |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | SRPR | chr11:126132837-126138750:- | 0.16 | 3.69 | 0.000239 | Schizophrenia |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | STT3A | chr11:125462739-125491280:+ | 0.15 | 3.58 | 0.000363 | Schizophrenia |
| BRCA | cis | rs7930295 | 1 | rs10893380 | chr11:125311674 | TIRAP | chr11:126152982-126164828:+ | 0.18 | 4.22 | 2.68E-5 | Schizophrenia |
| BRCA | cis | rs494003 | 1 | rs10896043 | chr11:65543827 | CTSW | chr11:65647284-65651212:+ | 0.17 | 6.25 | 5.91E-10 | Systemic lupus erythematosus |
| BRCA | cis | rs494003 | 1 | rs10896043 | chr11:65543827 | SNX32 | chr11:65601410-65621170:+ | -0.2 | -5.2 | 2.45E-7 | Systemic lupus erythematosus |
| BRCA | cis | rs11603691 | 1 | rs10896598 | chr11:57052007 | PRG2 | chr11:57151267-57191532:- | -0.21 | -3.6 | 0.000335 | Low high density lipoprotein cholesterol levels |